Born in Turin, Enzo Zirilli studied piano and percussion at his hometown Conservatory, but his jazz journey began with saxophonist Larry Nocella, a key figure in his artistic development, who gave him the opportunity to collaborate with other illustrious soloists: Franco Cerri, Gianni Basso, Antonio Faraò, Benny Bailey, and Flavio Boltro. In 1991, he toured with Gloria Gaynor.

At the same time, he continued his jazz collaborations, participating in Umbria Jazz with Antonio Faraò's quartet, which won the Four Roses award.

He consolidates his long-standing collaboration with Flavio Boltro and Stefano Di Battista and his artistic partnership with American saxophonist George Garzone, together with Luigi Tessarollo on guitar and Dario Deidda on bass, which will give rise to various tours and the recording of two CDs.

Since 1996 he has worked with Rossana Casale, with whom he has promoted several projects and recordings, including one dedicated to Jacques Brel.

He has collaborated for many years with Luigi Bonafede, with whom he plays in a trio or with guests (Pietro Tonolo, Roberto Rossi, Emanuele Cisi, Carlo Atti) and his partners include Dado Moroni and Enrico Pieranunzi.